Manufacture Supply Good Quality Rivaroxaban CAS 366789

Overview

Basic Info.

Model NO.	CAS 366789-02-8
Psa	116.42000
Logp	3.04080
Boiling Point	732.6°c at 760 Mmhg
Melting Point	228-234 ° C
Transport Package	25kg/Bag
Specification	chemical materials
Trademark	niuri
Origin	China
Production Capacity	500ton/Months

Product Description

Product Description

Product Name: Rivaroxaban
Synonyms: (S)-Rivaroxaban;(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carbox;RIVAROXABAN STAGE-IV [5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2(AS PER INV;5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide;BAY 59-7939;Rivaroxaban Isomer;Rivaroxaban;5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
CAS: 366789-02-8
MF: C19H18ClN3O5S
MW: 435.88
EINECS: 685-132-2
Melting point: 228-229°C
Boiling point: 732.6±60.0 °C
Density: 1.460±0.06 g/cm3
Storage temp.: Store at RT
Appearance: Off-White Powder
Description:
Venous thromboembolism continues to be a major health concern despite conventional anticoagulation therapies. Rivaroxaban is a recent market introduction that directly inhibits FXa with high potency (Ki=0.4 nM; IC50=0.7 nM) and selectivity>10,000-fold over other related serine (thrombin, trypsin, plasmin, FVIIa, FIXa, FXIa, urokinase, and activated protein C). From the X-ray crystal structure, the central oxazolidinone moiety anchors the drug through two hydrogen bonds to Gly219 and directs the morpholinone group into the S4 pocket and the chlorothiophene portion into the S1 pocket. These key components may be coupled together synthetically by a couple of routes. Condensation of 3-morpholinone with 4-fluoronitrobenzene followed by catalytic hydrogenation provides N-(p-aminophenyl)morpholinone for subsequent reaction with (S)-2-(phthalimidomethyl)oxirane. With establishment of the aminoalcohol adduct, cyclization with 1,1′-carbonyldiimidazole generates the central oxazolidinone. Deprotection and acylation with 5-chlorothiophene-2-carbonyl chloride affords rivaroxaban.
Uses:
Rivaroxaban is recommended as an option for treating pulmonary embolism and preventing recurrent deep vein thrombosis and pulmonary embolism in adults.
1. Rivaroxaban (Xarelto, Bayer) is indicated for the 'treatment of deep vein thrombosis and pulmonary embolism, and prevention of recurrent deep vein thrombosis and pulmonary embolism in adults'. For the initial treatment of acute pulmonary embolism, the recommended dosage of rivaroxaban is 15 mg twice daily for the first 21 days followed by 20 mg once daily for continued treatment and prevention of recurrent venous thromboembolism.
2. Non-Valvular Atrial Fibrillation (NVAF)* to prevent stroke & systemic embolism.
3. Acute VTE treatment & prevention of recurrent VTE [for deep vein thrombosis (DVT) and pulmonary embolism (PE)].
4. Prevention of venous thromboembolic events (VTE) in elective total hip or knee replacement surgery (THR, TKR).

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Packaging & ShippingPackage: 25Kg/Bag Transport: By sea By airport By express
Package&Shipping:------------------------------------------Packing: 1kg/bag,5kg/bag or 25kg/Hardboard drum or at your requirment 1KG : Double pharma-grade polybag inside,sealed Aluminum foil bag outside 5KG : Double pharma-grade polybag inside,Hardboard cartons outside 25KG: Double pharma-grade polybag inside,Hardboard drum outsideCompany Profile

Hebei Niuri Spraying Technology Co., Ltd. It was founded in 2021, located in Xingtai, Hebei Province, which is specialized in the research of production and trade of plastic material and pharmaceutical intermediate. Our products have spread over more than 50 countries in the world, Most of the products produced and sold are exported abroad, and it is well-received in all around the word for its excellent quality. At the same time in case to maintain good relations of cooperation with domestic manufactures, we actively develop new products, new customers and constantly meet the needs of customers at home and abroad. We sincerely welcome more clients to cooperate with us.

Our Advantages

1.Place of Origin China with Super quality by reasonable price.
2.Fast delivery by safe express way to all the country.
3.Has a number of highly qualified engineers and experts to provide guidance for reagents.
4.When you meet problems in mineral processing, we can provide technical guidance.
5.We can supply sample for testing.
6.We promise 100% deliveried,and 100% resend or refunds if parcel is not deliveried!

FAQ

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A: We are factory.
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A: Generally it is 5-10 days if the goods are in stock. or it is 15-20 days if the goods are not in stock, it is according to quantity.
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A: Yes, we could offer the sample for free charge but do not pay the cost of freight.
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