Rivaroxaban 366789

Basic Info.

Model NO.	JT22PHA
Colour	White
Application	a Novel Antithrombotic Agent
Delivery	by Sea, by Air, by Land/EMS/TNT/DHL/UPS/FedEx
Standard	Good Chemical Product
Storage Temp	Room Temperature and Avoid Light
Color	White
Assay	99%
Formula Weight	435.88
Name	Rivaroxaban
Transport Package	25kg/Bag, Customization
Specification	25kg,50kg,180kg,200kg,250kg,1000kg,customization
Trademark	Hubei Jiutian
Origin	Wuhan
HS Code	28369100
Production Capacity	15mt/Month

Product Description

Rivaroxaban Basic information(S)-Rivaroxaban;(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiop hene-2-carbox;RIVAROXABAN STAGE-IV [5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2(AS PER INV;5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiop enecarboxamide;BAY 59-7939;Rivaroxaban Isomer;Rivaroxaban;5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thioph ene-2-carboxamideRivaroxaban is a pure (S)-enantiomer. It is an odorless, non-hygroscopic, white to yellowish powder. Rivaroxaban is only slightly soluble in organic solvents (e.g., aceto ne, polyethylene glycol 400) and is practically insoluble in water and aqueous media.Rivaroxaban, a FXa inhibitor, is the active ingredient in XARELTO Tablets. XARELTO a kind of orally anticoagulant drug which is used for the prevention of blood clots. Rivaroxaban takes effect through competitively inhibiting free and clot bound factor Xa, which is needed to activate prothrombin (factor II) to thrombin (factor IIa). The later is a serine protease that is required to activate fibrinogen to fibrin, which is the loose meshwork that completes the clotting process.Each XARELTO tablet contains 10 mg, 15 mg, or 20 mg of rivaroxaban. The inactive ingredients of XARELTO are: croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate. Additionally, the proprietary film coating mixture used for XARELTO 10 mg tablets is Opadry(R) Pink and for XARELTO 15 mg tablets is Opadry(R) Red, both containing ferric oxide red, hypromellose, polyethylene glycol 3350, and titanium dioxide, and for XARELTO 20 mg tablets is Opadry(R) II Dark Red, containing ferric oxide red, polyethylene glycol 3350, polyvinyl alcohol (partially hydrolyzed), talc, and titanium dioxide.Rivaroxaban is an antithrombotic drug and was developed in a collaboration between the German Bayer Pharmaceuticals and American Johnson company. It is different from the traditional antithrombotic drug heparin in that Rivaroxaban does not need the participation of antithrombin III and can directly antagonize free and bound Xa factors. Heparin requires the effects of antithrombin III, and has no effect on Xa factors in the prothrombin complex. Rivaroxaban is the first oral direct Xa factor inhibitor in the whole world, and it can selectively and competitively inhibit free and bound Da factors as well as prothrombin activity. It uses a dose-dependent method to extend the partial thromboplastin time (PTT) and activated partial thromboplastin time (aPTT) to extend clotting time and lower thrombin genesis. Rivaroxaban has the characteristics of high bioavailability, wide range of target diseases, stable dose-effect relationship, easy oral intake, and low bleeding risk.Rivaroxaban can also prevent and treat venous thrombosis. It is mainly used clinically to prevent deep venous thrombosis (DVT) and pulmonary embolism (PE) in adult patients following hip and knee replacement surgery. It is also used to prevent patients with nonvalvular atrial fibrillation from cerebral apoplexy and noncentral nervous system embolism, and it can lower the recurrence risk of coronary syndromes.Rivaroxaban is recommended as an option for treating pulmonary embolism and preventing recurrent deep vein thrombosis and pulmonary embolism in adults.
1.Rivaroxaban (Xarelto, Bayer) is indicated for the 'treatment of deep vein thrombosis and pulmonary embolism, and prevention of recurrent deep vein thrombosis and pulmonary embolism in adults'. For the initial treatment of acute pulmonary embolism, the recommended dosage of rivaroxaban is 15 mg twice daily for the first 21 days followed by 20 mg once daily for continued treatment and prevention of recurrent venous thromboembolism.
2.Non-Valvular Atrial Fibrillation (NVAF)* to prevent stroke & systemic embolism.
3.Acute VTE treatment & prevention of recurrent VTE [for deep vein thrombosis (DVT) and pulmonary embolism (PE)].
4.Prevention of venous thromboembolic events (VTE) in elective total hip or knee replacement surgery (THR, TKR).
product details

Item	parameter
Name	Rivaroxaban
Synonyms	(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiop hene-2-carbox
CAS	366789-02-8
Molecular Formula	C19H18ClN3O5S
Formula Weight	435.88
Appearance	White powder
Melting Point	228-229°C
Boiling point	732.6±60.0 °C(Predicted)
Assay	99%
Water	<0.5%
Residue on ignition	<0.5%
Stability	Stable
Storage Temp	room temperature and avoid light
Origin	Wuhan China
Application	A novel antithrombotic agent
Delivery	by sea,by air,by Land/EMS/TNT/DHL/UPS/FedEx

Packing

Liquid products

• 25kg,50kg,180kg,200kg,250kg,1000kg,as your needs

Solid products

• 25kg,50kg,as your needs

Shipping

Logistics transportation methods can be divided into various ways according to the different transportation means.

• Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.• For mass orders, it will be delivered by air or sea.• Depending on your location, please allow 1-5 business days for your order to arrive.• For small order, please expect 3-7 days by UPS DHL EMS.• For mass order, please allow 5-8 days by Air, 15-30 days by Sea.

Our service

• We have our own research and development team, laboratory, pilot workshop and production plant.
• Factory production has the most stable and the best production processes, to ensure that you are given the best prices and the highest quality products.
• Not only do we provide our customers with products, but we also provide them with free product usage methods and subsequent technical guidance
• The customer comes first, we provide reasonable price, high quality product and prompt shipment.
• We can send the goods to your delivery address directly. It is relatively safe and fast. We have ready goods in stock.
• Quick and clear response to customers questions.Warm after sale service, we will help to solve the problems in your usage.
• We could make our price discount if you place a substantial order with us.

Our Advantages

• Your inquiry related to our products or prices will be replied in 24 hours.
• We have our own research and development team, laboratory, pilot workshop and production plant.
• Factory production has the most stable and the best production processes, to ensure that you are given the best prices and the highest quality products.
• Not only do we provide our customers with products, but we also provide them with free product usage methods and subsequent technical guidance
• Protection of your sales area, ideas of design and all your private information.
• Best quality and competitive price.

Frequently Asked Question

• Q1: Can I get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by customers.

• Q2: How to start orders or make payments?A : PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union LC,Moneygram or Paypal.

• Q3: What's your MOQ?A : Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.• Q4: How about delivery leadtime?A : Delivery lead time: About 3-5 days after payment confirmed.(Chinese holiday not

included)

• Q5: Is there a discount?A : Different quantity has different discount.

• Q6: How to contact us ?A : You can chat with us by Trademanager,MSN&Skype Online. You can choose your interested products and send inquiry to us. You can dial our telephone directly, you will get our reply. Send Email to us.

• Q7: How to confirm the Product Quality before placing orders?A : You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Our R&D laboratory Our Factory

Detecting chamber
Quality
We strictly emphasize that products we provide will satisfy or exceed the quality standard of customer.This is to guarantee deliveries of safe and high quality products with reliable services.We promote the philosophy of treating everyone with objectivity and respect.We will honor our commitments with our customers,suppliers,and respect.We through unbiased pricing,products,and honesty.Factories and workshops
We is located in wuhan, the central city of China, the core of the Changjiang river economic belt and known as the "thoroughfare of nine provinces".Mainly engaged in Pharmaceuticals Raw Material, Pesticides Raw Materials, API Raw Material, OLED Intermediates, UV Absorber Additive, Chemical Food Additives, Plant Extract Powder, Chinese Herbal Medicine, Polyimide Monomer, Impurity Reference Standards research and development, production, sales and operation or agency of various products and technology import and export business.