192725

Basic Info.

Model NO.	192725-17-0
Standard	USP/Ep/Bp/Cp/IP/Jp/Who/in-House
Capacity	1000kg/Mon
Transport Package	25kg/Drum/1000g/Bag/10g/Bag
Specification	100% raw material
Trademark	Widely
Origin	China
Production Capacity	1000kg/Mon

Product Description

Description	Lopinavir, the sixth HIV protease inhibitor in the "navir" class, was launched in coformulation with ritonavir, another HIV protease inhibitor already marketed (Abbott, 1996); this original formulation was introduced as Kaletra for use in combination with either nucleoside or non-nucleoside reverse transcriptase inhibitors for the treatment of AIDS in adults and children. Lopinavir is a peptidomimetic compound with a structural core identical to that of ritonavir, on which terminal groups, particularly a modified valine, were introduced by peptide coupling procedures. Lopinavir is a potent competitive inhibitor of HIV-I protease exhibiting high potential against ritonavir-resistant mutations. In several animal species, pharmacokinetic studies with the lopinavirlritonavir association showed that the modest properties of lopinavir were significantly improved in presence of ritonavir, in terms of Cmax and duration of action. Ritonavir inhibits the P450 isoenzyme CYP3A4 and the human liver microsomal metabolism of lopinavir, so strongly amplifying plasma levels of this latter component. In AIDS patients, the plasma HIV RNA level was considerably reduced and the CD4+ T-cell counts increased after administration of lopinavir combined with relatively small doses of ritonavir. Kaletra is intended to be used jointly with other antiretroviral agents.
Chemical Properties	Lopinavir is a white to light tan powder. It is freely soluble in methanol and ethanol, soluble in isopropanol and practically insoluble in water.
Originator	Abbott (US)
Uses	Lopinavir has been used as a ZMPSTE24 and human immunodeficiency virus protease inhibitor.
Uses	A selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral.
Uses	Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM
Definition	ChEBI: Lopinavir is a dicarboxylic acid diamide that is amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha- to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class, it is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir. It has a role as an antiviral drug, a HIV protease inhibitor and an anticoronaviral agent. It is a member of amphetamines and a dicarboxylic acid diamide.

Hubei weideli Chemical Reagent Co., Ltd., located in Wuhan East Lake New Technology Development Zone, is a manufacturing supplier focusing on reagent products for scientific research, and its business scope includes the manufacturing of special chemical products; Disinfectant production; Sales of special chemical products; Disinfectant sales; Research and development of biological feed; Research and development of bio based materials technology; Research and development of biochemical products technology; Technical services, technical development, technical consultation, technical exchange, technology transfer and technology promotion; Sales of instruments and meters; Sales of daily glass products; Sales of technical glass products; Sales of electronic special materials; Technology import and export; Import and export of goods; Veterinary drug management; Production of disinfection products for the prevention and treatment of infectious diseases.The company has gradually established extensive cooperation with scientific research institutions in Colleges and universities and powerful enterprises to lay a solid foundation for technological production; At the same time, we will recruit talents all over the country and keep them fresh and energetic; With more than ten years of experience and accumulation in the industry, the company further improves its market competitiveness and strengthens its support to customers.With the help of modern ERP system, the company provides customers with accurate quotation and inventory information in time. It has a warehouse base and Laboratory of more than 1000 square meters in Jiangxia District, Wuhan. The system inventory products can be ordered on the same day, and the order number is given on the same day of delivery. The information can be queried online, followed up in real time, and customer service provides after-sales support services.Hubei weideli Chemical Reagent Co., Ltd. is committed to scientific research.

I. Do you always have this products in stock?Our company has more than 1000 kinds of products in stock. We usually have them in stock. We can show you the information, forms or pictures of our warehouse at any time. If the stock is insufficient, our company will replenish them as soon as possible according to the ERP system.2. What certificates and documents do you offer?According to the situation of products, we can provide COA, NMR, LC, MS, synthesis process, MQA, MSDS, etc3. Why should I choose you?Stock in stock and deliver in timeReasonable priceProduct technology and data supportProfessional sales teamPerfect pre-sale and after-sale service4. Can I get best price from you?We don* t pursue expensive profitsWe always try to give best offerYou can also enjoy fun of bargaining5. How should I pay?T/T bank transfer West union PayPal